20 Sept 2018 A Ray of Molecular Beauty from Cryo-EM
NIH Director’s Blog
15 March 2017 Van Andel Institute Happenings
Xu T-H, Liu M, Zhou XE, Liang G, Zhao G, Xu HE, Melcher K, Jones PA. 2020. Structure of DNA methyltransferases DNMT3A/DNMT3B bound to a nucleosome. Nature. 586:151-155.
Zhao LH* et al.. 2019. Structure and dynamics of the active human parathyroid hormone receptor-1. Science.
Zhou XE et al. 2017. Identification of phosphorylation codes for arrestin recruitment by G protein-coupled receptors. Cell.
*Cover of Cell
Zhang F et al. Structural basis of JAZ-mediated repression of MYC transcription factors in jasmonate signaling. Nature.
Li X et al. Structural basis of AMPK regulation by adenine nucleotides and glycogen. Cell Res.
Chen C et al. Structural basis for molecular recognition of folic acid by folate receptors. Nature.
DeBruine ZJ et al. Wnt5a promotes Frizzled-4 signalosome assembly by stabilizing cysteine-rich domain dimerization. Genes Dev.
Soon F-F et al. Molecular mimicry regulates ABA signaling by SnRK2 kinases and PP2C phosphatases. Science.
Melcher K et al. A gate-latch-lock mechanism for hormone signaling by abscisic acid receptors. Nature.
A fully funded postdoctoral or research scientist position is available immediately in the Melcher Laboratory. We are seeking a highly motivated individual interested in applying cutting-edge structural biology and protein biochemistry techniques to study signaling mechanisms. VAI has state-of-the-art crystallization and cryo-electron microscopy facilities. This position will provide excellent training and career advancement opportunities. Read more and apply here.